{"repo":"Optimized-Brain/MutAIon","free":true,"listed":false,"github":"https://github.com/Optimized-Brain/MutAIon","clone":"git clone https://github.com/Optimized-Brain/MutAIon.git","description":"A Full Stack Variant Effect Predictor leveraging the Evo2 LLM for Single Nucleotide Variant(SNV) pathogenicity analysis, powered by a Modal‑deployed FastAPI GPU backend and a Next.js + Shadcn UI frontend","language":"TypeScript","stars":42,"topics":["bioinformatics","evo2","large-language-model","mutation-analysis","nextjs","pytorch"],"license":null,"category":"machine-learning","readme_excerpt":"MutAIon - LLM based Variant Analysis WebApp This project implements a web application for variant effect prediction, leveraging the Evo2 large language model to determine the pathogenicity of single nucleotide variants (SNVs). It includes: Python Backend : A FastAPI service running on an H100 GPU via Modal serverless infrastructure. AI Model : Evo2 for classifying SNVs as pathogenic or benign. Database Integration : Fetches ClinVar classifications for comparison. Frontend : Built with Next.js, React, TypeScript, Tailwind CSS, and Shadcn UI (T3 Stack). Features : Genome assembly selection Chromosome browsing and gene search (e.g., BRCA1) Reference genome display Mutation input and prediction Comparison with ClinVar data Architecture Backend Framework : FastAPI Deployment : Modal serverless GPU (H100) Endpoint : /predict accepts gene, position, reference and alternative alleles, returns pathogenicity score and label. Dependencies : evo2 , modal , fastapi , uvicorn , sqlalchemy , requests Frontend Framework : Next.js with TypeScript Styling : Tailwind CSS Components : Shadcn UI (Buttons, Inputs, Cards) Pages : / Assembly selection /browse/[assembly] Chromosome listing /gene/[geneId] Gene details and sequence API Integration : Uses React Query to call FastAPI endpoints. Setup Prerequisites Node.js = 18 Python 3.10+ Modal CLI and account Backend Installation Frontend Installation Usage 1. Launch backend via Modal. 2. Start frontend in development mode. 3. Navigate to http://localh","default_branch":null,"files":null,"tree":[],"storefront":"/r/Optimized-Brain","claimed":false,"request_supported":{"post":"https://gitbuyer.com/r/Optimized-Brain/MutAIon/request-supported","requests":0},"note":"indexed from public GitHub; nothing is for sale on this page. Clone it from GitHub. Paid listings live at /search."}