{"repo":"MannLabs/alphatims","free":true,"listed":false,"github":"https://github.com/MannLabs/alphatims","clone":"git clone https://github.com/MannLabs/alphatims.git","description":"An open-source Python package for efficient accession and visualization of Bruker TimsTOF raw data from the Mann Labs at the Max Planck Institute of Biochemistry.","language":"Python","stars":98,"topics":["mass-spectrometry","dda","dia","ms","lc-tims-msms","tof","tims","python","cli","gui"],"license":"Apache-2.0","category":"cli-tools","readme_excerpt":"AlphaTims --- AlphaTims Publication · Download · Installation · Usage · Documentation · alphapept.org AlphaTims is an open-source Python package that provides fast accession and visualization of unprocessed LC-TIMS-Q-TOF data from Bruker’s timsTOF Pro instruments. It indexes the data such that it can easily be sliced along all five dimensions: LC, TIMS, QUADRUPOLE, TOF and DETECTOR. It was developed by the Mann Labs at the Max Planck Institute of Biochemistry as a modular tool of the AlphaPept ecosystem. To enable all hyperlinks in this document, please view it at GitHub. --- About High-resolution quadrupole time-of-flight (Q-TOF) tandem mass spectrometry can be coupled to several other analytical techniques such as liquid chromatography (LC) and trapped ion mobility spectrometry (TIMS). LC-TIMS-Q-TOF has gained considerable interest since the introduction of the Parallel Accumulation–Serial Fragmentation (PASEF) method in both data-dependent (DDA) and data-independent acquisition (DIA). With this setup, ion intensity values are acquired as a function of the chromatographic retention time, ion mobility, quadrupole mass to charge and TOF mass to charge. As these five-dimensional data points are detected at GHz rates, datasets often contain billions of data points which makes them impractical and slow to access. Raw data are therefore frequently binned for faster data analysis or visualization. In contrast, AlphaTims is a Python package that provides fast accession and visualiz","default_branch":null,"files":null,"tree":[],"storefront":"/r/MannLabs","claimed":false,"request_supported":{"post":"https://gitbuyer.com/r/MannLabs/alphatims/request-supported","requests":0},"note":"indexed from public GitHub; nothing is for sale on this page. Clone it from GitHub. Paid listings live at /search."}